Chen YC, Lin YH, and Huang JR* "Convergent evolution of intrinsically disordered regions of galectins in vertebrates for liquid-liquid phase separation" in preparation
Lin PH, Wu GW, Lin YH, Huang JR, Jeng US, Liu WM*, and Huang JR* "TDP-43 amyloid fibril formation via phase separation-related and -unrelated pathways" submitted
Sun YC, Hsieh TL, Lin CY, Shao WY, Lin YH,and Huang JR*. "A few charged residues in a protein’s folded and disordered regions regulate phase separation" submitted
Chou PC, Huang YC, Hong SR, Lin YH, Chang TJ, Lin Y, Lin YH, Yang TT, Lin YC, Huang JR*, Wang WC*. "Phase separation of TTBK2 and CEP164 is necessary for ciliogenesis" under revision
Ho WL, Huang HC, and Huang JR*. "IFF: Identifying key residues in intrinsically disordered regions of proteins using machine learning" (2023) Prot Sci 3;32:e4739
Chiu SH, Ho WL, Sun YC, Kuo JC, and Huang JR*. "Phase separation driven by interchangeable properties in the intrinsically disordered regions of protein paralogs" (2022) Comm. Biol. 5:400
Ho WL and Huang JR*. "The return of the rings: Evolutionary convergence of aromatic residues in the intrinsically disordered regions of RNA-binding proteins for liquid–liquid phase separation." (2022) Prot Sci 31:e4317
Chiang WC, Lee MH, Chen TC, and Huang JR*. "Interactions between the Intrinsically Disordered Regions of hnRNP-A2 and TDP-43 Accelerate TDP-43′s Conformational Transition." (2020) Int J Mol Sci. 21(16), 5930
Chen TC and Huang JR*. "Musashi-1: An Example of How Polyalanine Tracts Contribute to Self-Association in the Intrinsically Disordered Regions of RNA-Binding Proteins." (2020) Int J Mol Sci. 21(7). pii: E2289
Chiu YP, Sun YC, Qiu DC, Lin YH, Chen YQ, Kuo JC, and Huang JR*. "Liquid-liquid phase separation and extracellular multivalent interactions in the tale of galectin-3" (2020) Nat Comm 11:1229
Li HR, Chiang WC, Chou PC, Wang WJ, Huang JR*. "TAR DNA-binding protein 43 (TDP-43) liquid-liquid phase separation is mediated by just a few aromatic residues" (2018) J Biol Chem 293(16):6090-6098
Li HR, Chen TC, Hsiao CL, Shi L, Chou CY, Huang JR*. "The physical forces mediating self-association and phase-separation in the C-terminal domain of TDP-43." (2018) BBA-Proteins and Proteomics 1866:214-223
Lin YH, Qiu DC, Chang WH, Yeh YQ, Jeng US, Liu FT, Huang JR*. "The intrinsically disordered N-terminal domain of galectin-3 dynamically mediates multisite self-association of the protein through fuzzy interactions." (2017) J Biol Chem 292(43) 17845–17856
Chen TC, Hsiao CL, Huang SJ, Huang JR*. "The nearest-neighbor effect on random-coil NMR chemical shifts demonstrated using a low-complexity amino-acid sequence." (2016) Protein Pept Lett. 23(11):967-975
學生/博後時期
Huang JR, Warner LR, Sanchez C, Gabel F, Madl T, Mackereth CD, Sattler M, Blackledge M. "Transient electrostatic interactions dominate the conformational equilibrium sampled by multi-domain splicing factor U2AF65: A combined NMR and SAXS study." (2014) J Am Chem Soc 136(19):7068-76
Huang JR, Ozenne V, Jensen MR, and Blackledge M. “Direct prediction of NMR residual dipolar couplings from the primary sequence of unfolded proteins ” (2013) Angew Chem Int Ed 52(2):687-690 (Cover Issue)
Huang JR, Gentner M, Vajpai N, Grzesiek S, and Blackledge M. “Residual dipolar couplings measured in unfolded proteins are sensitive to amino- acid specific geometries as well as local conformational sampling” (2012) Biochem Soc T 40(5):989-94
Huang JR, Gabel F, Jensen MR, Grzesiek S, and Blackledge M. “Sequencespecific mapping of the interaction between urea and unfolded ubiquitin from ensemble analysis of NMR and small angle scattering data.” (2012) J Am Chem Soc 134(9):4429-36
Huang JR and Grzesiek S. “Ensemble calculations of unstructured proteins constrained by RDC and PRE data: a case study of urea-denatured ubiquitin.” (2010) J Am Chem Soc 132(2):694-705
Huang JR, Hsu S-TD, Christodoulou J, and Jackson SE. “The extremely slow-exchanging core and acid-denatured state of Green Fluorescent Pro- tein.” (2008) HFSP Journal 2(6):378-87
Huang JR, Craggs TD, Christodoulou J, and Jackson SE. “Stable intermediate states and high energy barriers in the unfolding of GFP.” (2007) J Mol Biol 370(2):356-71
其它合作成果
Siew JJ, Chen HM, Chiu FL, Lee CW, Chang YM, Chen HL, Nguyen TNA, Liao HT, Liu M, Hagar HT, Sun YC, Lai HL, Kuo MH, Blum D, Buee L, Jin LW, Chen SY, Ko TM, Huang JR, Kuo HC, Liu FT, and Chern Y. "Galectin-3 aggravates microglial activation and tau transmission in tauopathy." (2023) J Clin Invest
Chou MC, Wang YH, Chen FY, Kung CY, Wu KP, Kuo JC, Chan SJ, Cheng ML, Lin CY, Chou YC, Ho MC, Firestine S, Jie-rong Huang, Chen RH. "PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly" (2023) Mol Cell
Hsiao CT, Cheng HW, Huang CM, Li HR, Ou MH, Huang JR, Khoo KH, Yu HW, Chen YQ, Wang YK, Chiou A, Kuo JC. “Fibronectin in cell adhesion and migration via N-glycosylation” (2017) Oncotarget 8(41):70653-70668.
Jensen MR, Zweckstetter M, Huang JR, Blackledge M. “Exploring Free-Energy Landscapes of Intrinsically Disordered Proteins at Atomic Resolution Using NMR Spectroscopy.” (2014) Chem Rev 114(13):6632-60
Ozenne V, Schneider R, Yao M, Huang JR, Salmon L, Zweckstetter M, Jensen MR and Blackledge M. “Mapping the potential energy landscape of intrinsically disordered proteins at amino acid resolution” (2012) J Am Chem Soc 134(36):15138-48
Ozenne V, Bauer F, Salmon L, Huang JR, Jensen MR, Segard S, Bernado P, Charavay C, and Blackledge M. ”Flexible-meccano: A tool for the generation of explicit ensemble description of intrinsically dis- ordered proteins and their associated experimental observables” (2012) Bioinfomatics 28(11):1463-70
Silvers R, Sziegat F, Tachibana H, Segawa S, Whittaker S, Gunther U, Gabel F, Huang JR, Blackledge M, Wirmer J, and Schwalbe H. “Modulation of structure and dynamics by disulfide bond formation in unfolded states.” (2012) J Am Chem Soc 134(15):6846-54
Schneider R, Huang JR, Yao M, Communie G, Ozenne V, Mollica L, Salmon L, Jensen MR, and Blackledge M. “Towards a robust descrip- tion of intrinsic protein disorder using nuclear magnetic resonance spec- troscopy.” (2012) Mol Biosyst 8(1):58-68
Vajpai N, Gentner M, Huang JR, Blackledge M, and Grzesiek S. “Sidechain χ1 conformations in urea-denatured ubiquitin and protein G from 3J coupling constants and residual dipolar couplings.” (2010) J Am Chem Soc 132(9):3196-203
Haussinger D, Huang JR, and Grzesiek S. “DOTA-M8–an extremely rigid, high-affinity lanthanide chelating tag for PCS NMR.” (2009) J Am Chem Soc 131(41):14761-7
Jackson SE, Craggs TD, Huang JR. “Understanding the folding of GFP using biophysical techniques.” (2006) Expert Rev Proteomics 3(5):545-59
